Mercury and Acrodynia
Infantile acrodynia, also called Pink Disease, was a disorder that was prevalent in the first half of the 20th century that occurred in infants and young children. According to the research literature, the earliest symptoms were emotional in nature where a lively baby becomes increasingly apathetic. In reading these early descriptions of infants and young children diagnosed with Pink Disease there are numerous overlaps between the acrodynia and autism. These include: depression, apathy, fretfulness, loss of appetite, social withdrawal, photophobia sweating, hypotonia, misery, slurring or loss of speech, and insomnia. Hand banging, rocking, parathesias in the extremities, occasional tremor, convulsions and gastrointestinal disturbances were also reported. The cause of infantile acrodynia evaded the medical community until 1945 when 12 of 14 children diagnosed with Pink Disease were found to have elevated mercury levels. The culprit was recognized as infant teething powders that contained calomel (mercurious chloride). Following the removal of calomel from teething powders in 1954 the disease disappeared. Even though teething powders that contained mercury were widely used at the time, only about 1 out of every 500 children exposed developed the disorder which was consider to be a hypersensitivity to mercury.